Category: Medicine

Health

Variations of Oral Bacteria May Signal Pancreatic Cancer

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According to a new study conducted at the UCLA David Geffen School of Medicine.

Abstract

Objective The associations between oral diseases and increased risk of pancreatic cancer have been reported in several prospective cohort studies. In this study, we measured variations of salivary microbiota and evaluated their potential associations with pancreatic cancer and chronic pancreatitis.

Methods This study was divided into three phases: (1) microbial profiling using the Human Oral Microbe Identification Microarray to investigate salivary microbiota variation between 10 resectable patients with pancreatic cancer and 10 matched healthy controls, (2) identification and verification of bacterial candidates by real-time quantitative PCR (qPCR) and (3) validation of bacterial candidates by qPCR on an independent cohort of 28 resectable pancreatic cancer, 28 matched healthy control and 27 chronic pancreatitis samples.

Results Comprehensive comparison of the salivary microbiota between patients with pancreatic cancer and healthy control subjects revealed a significant variation of salivary microflora. Thirty-one bacterial species/clusters were increased in the saliva of patients with pancreatic cancer (n=10) in comparison to those of the healthy controls (n=10), whereas 25 bacterial species/clusters were decreased. Two out of six bacterial candidates (Neisseria elongata and Streptococcus mitis) were validated using the independent samples, showing significant variation (p<0.05, qPCR) between patients with pancreatic cancer and controls (n=56). Additionally, two bacteria (Granulicatella adiacens and S mitis) showed significant variation (p<0.05, qPCR) between chronic pancreatitis samples and controls (n=55). The combination of two bacterial biomarkers (N elongata and S mitis) yielded a receiver operating characteristic plot area under the curve value of 0.90 (95% CI 0.78 to 0.96, p<0.0001) with a 96.4% sensitivity and 82.1% specificity in distinguishing patients with pancreatic cancer from healthy subjects.

Conclusions The authors observed associations between variations of patients’ salivary microbiota with pancreatic cancer and chronic pancreatitis. This report also provides proof of salivary microbiota as an informative source for discovering non-invasive biomarkers of systemic diseases.

How profound will this oral biomarker be, when you can go to your physician or dentist, have a saliva sample taken and be screened for the “silent killer” of pancreatic cancer? Early treatment regeimes could then be devised.

And, how about other diseases, including other cancers?

Exciting work…..

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Health

Smokers Suffer Heart Attacks at a Younger Age

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According to a new study.

Smokers tend to suffer heart attacks years earlier than non-smokers, suggests a new study from Michigan.

“Individuals who smoke are much more likely to have a heart attack, and will present with a heart attack a decade or more earlier,” said Dr. Gregg Fonarow, a cardiologist at the David Geffen School of Medicine at the University of California, Los Angeles, who wasn’t involved in the new study.

The findings, he said, also show that people who smoke “could have a heart attack in the absence of other risk factors.”

Researchers led by Dr. Michael Howe from the University of Michigan Health System in Ann Arbor studied about 3,600 people who were hospitalized with a heart attack or unstable angina.

One-quarter of the patients were current smokers. And on average, they were younger with fewer health problems than non-smokers with heart trouble.

The mean ages at hospital admission were 64 for non-smoking men vs 55 for male smokers. For women, mean ages were 70 for non-smokers and 57 for smokers.

Smokers were less likely to have other health problems that are linked to cardiac risks, including high cholesterol, high blood pressure and diabetes.

That and their younger age explained why researchers also found that smokers were less likely to die in the six months following the index event than non-smokers.

That “smoker’s paradox” — the idea that smokers who have a heart attack have better outcomes, including a lower risk of death — didn’t last. The difference in death over the next six months was explained by age and other risk factors.

Dr. Fonarow said the findings are just one more example of the heart dangers posed by smoking, but emphasized that kicking the habit can erase those extra risks.

“Even within a few days of stopping smoking, there is a reduction in (heart) risk. As time goes by, within one to two years much of that risk is gone for heart attacks,” he told Reuters Health. “From a coronary risk standpoint, there is an immediate benefit and that continues to extend over time.”

Smoking is just a very bad risk factor for cardiac disease.

You know how I feel.

Please quit if you can and don’t start…..

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Diet

Vitamin E Supplements May Increase Risk for Prostate Cancer?

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YES, according to a new study.

Men who take a daily vitamin E supplement — a regimen once thought to reduce cancer risk — face an increased risk of prostate cancer, according to results of a large national study.

The finding comes from a report summarizing the latest results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Eric Klein, M.D., chair of the Glickman Urological and Kidney Institute at Cleveland Clinic, is the lead author.

SELECT began in 2001 to test earlier research suggesting selenium and vitamin E supplements may reduce the risk of developing certain cancers. Some vitamin supplements containing enhanced levels of selenium and vitamin E were marketed to consumers during this time period with claims of reducing cancer risk.

The paper, which will appear in the October 12 edition of the Journal of the American Medical Association, found that a group of men taking a daily dose of 400 IU of vitamin E from 2001 to 2008 had 17 percent more cases of prostate cancer than men who took a placebo.

“For the typical man, there appears to be no benefit in taking vitamin E, and in fact, there may be some harm,” said Dr. Klein, an internationally renowned prostate cancer expert who served as the national study coordinator.

Prostate cancer is the most common non-skin cancer in American men with a current lifetime risk of 16 percent. For 2011 it is estimated 240,000 new cases and 33,000 deaths will result in the U.S.

Well, I am not taking a vitamin E supplement and will not start now. I am taking a vitamin D supplement, but will discuss continuing this with my physician at my annual physical  exam next month.

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Health

Pregnant Runner Completes Chicago Marathon – Then Delivers Baby

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Amber Miller Gives Birth After Chicago Marathon

Truly amazing.

Amber Miller accomplished two monumental feats this weekend.

Days from her due date, the 27-year-old joined 45,000 other runners to participate in Sunday’s Bank of America Chicago Marathon and then gave birth to a baby girl named June hours later.

Miller, an avid runner, said she signed up for the 26.2-mile race before finding out she was pregnant. She said she never expected to finish the race.

“I was having a conversation with my parents and said, ‘You know what? I have no plans of actually finishing,'” she told reporters at Central DuPage Hospital this morning. “I was planning on running half, skipping to the end, then walking across the finish line.”

But Miller and her husband started running, and just kept going. They ran part of the race and walked the second half as her contractions started. It took the couple 6.5 hours to finish. She said she grabbed something to eat and the two headed to the hospital.

At 7 pounds, 13 ounces, baby June entered the world at 10:29 p.m. Sunday, just hours after her parents crossed the finish line.

Congratulations and I guess this answers the question as to whether YOU should train for a marathon!

Just do it!

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Diet

Poll Watch: More Americans a Normal Weight Than Overweight

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According to the latest Gallup Poll.

The percentage of Americans who are overweight or obese declined slightly in the third quarter of 2011, while the percentage who are a normal weight increased. For the first time in more than three years, more Americans are a normal weight (36.6%) than are overweight (35.8%).

The overweight and normal weight trend lines have tracked closely together since Gallup and Healthways started monitoring Americans’ weight situation daily in January 2008. Though it is noteworthy that more adults are now a normal weight than overweight, it is too early to tell if this shift is temporary or permanent.

The recent slight decline in the nation’s obesity rate is a positive contrast to the rising levels found in 2009 and throughout most of 2010. However, the majority of Americans are still at an unhealthy weight — either overweight or obese (61.6%).

The Gallup-Healthways Well-Being Index uses respondents’ self-reports of their height and weight to calculate body mass index (BMI) scores. Individual BMI values of 30 or higher are classified as “obese,” 25.0 to 29.9 are “overweight,” 18.5 to 24.9 are “normal weight,” and 18.4 or less are “underweight.”

Good news, but there is still more weight to lose.

Obesity Rates Down Across Demographic Groups

Black Americans, the middle-aged, and those with low incomes remain the most likely to be obese across major demographic subgroups in an aggregate of the data collected in all three quarters of 2011 — as generally has been the case historically.

However, obesity rates for each of those groups and all others included in this analysis are either trending down or are statistically unchanged so far in 2011.

The chart:

So, what does this all mean?

Although a majority of Americans remain overweight or obese, it is a good sign that the obesity rates are trending downward. Perhaps Americans are learning more about adopting a healthy diet and exercise program. Perhaps it is the economic recession and folks are eating out less at fast-food restaurants that have menus that are high in caloric and fat content?

It is hard to say.

But, let’s hope that the trend continues in a downward direction = for better health.

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